|
KMID : 0378019870300080045
|
|
New Medical Journal
1987 Volume.30 No. 8 p.45 ~ p.52
|
|
|
Histological study on the effect of hemorrhage to steroid-induced avascular necrosis in rabbits
|
|
|
|
|
Abstract
|
|
|
This study was undertaken in an attempt to investigate steroid-treated rabbits through histological findings of lung, kidney, liver, and femoral head whether avascular necrosis of bone might be influenced by, primary hemorrhage due to possible vascular damage or secondary hemorrhage caused by fatty cell hyperplasia.
Of twelve adult rabbits, nine were administered a weekly dose of eight mg of methylprednisolone from three to eight weeks and three served as control. All specimens of lung, kindney, liver and femoral head from each three rabbits at three, four, and eight weeks after the initial administration of steroid injection were studied on their histological change mainly regarding hemorrhage related to vascular change, fatty hyperplasia, subchondral fracture, and cell necrosis.
The results of those histological findings are summarized as follows:
All specimens of lung, kidney, liver and femoral head revealed early hemorrhage, possibly related to damage of the vascular wall rather than fatty cell hyperplasia, but the liver was shown to have much more fatty metamorphosis, as same as hemorrhage and necrosis. It is concluded that steroid-induced avascular necrosis of bone might be affected by hemmorhage due to possible vascular damage and more aggravated by fatty hyperplasia.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|